IP₃-Dependent Ca²⁺ Oscillations Switch into a Dual Oscillator Mechanism in the Presence of PLC-Linked Hormones.

ABSTRACT: Ca²⁺ oscillations that depend on inositol-1,4,5-trisphosphate (IP₃) have been ascribed to biphasic Ca²⁺ regulation of the IP₃ receptor (IP₃R) or feedback mechanisms controlling IP₃ levels in different cell types. IP₃ uncaging in hepatocytes elicits Ca²⁺ transients that are often localized at the subcellular level and increase in magnitude with stimulus strength. However, this does not reproduce the broad baseline-separated global Ca²⁺ oscillations elicited by vasopressin. Addition of hormone to cells activated by IP₃ uncaging initiates a qualitative transition from high-frequency spatially disorganized Ca²⁺ transients, to low-frequency, oscillatory Ca²⁺ waves

SUBMITTER: Bartlett PJ 

PROVIDER: S-EPMC7191650 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature