The influence of balanced complex chromosomal rearrangements on preimplantation embryonic development potential and molecular karyotype.

ABSTRACT:

Background

Balanced complex chromosome rearrangements (BCCR) are balanced chromosomal structural aberrations that involve two or more chromosomes and at least three breakpoints. It is very rare in the population. The objective is to explore the difference of influence of three types of BCCR on early embryonic development and molecular karyotype.

Results

Twelve couples were recruited including four couples of three-way rearrangements carriers (group A), three couples of double two-way translocations carriers (group B) and five couples of exceptional CCR carriers (group C). A total of 243 oocytes were retrievedin the seventeen preimplantation genetic testing (PGT) cycles, and 207 of these were available for fertilization. After intracytoplasmic sperm injection, 181oocytes norm

SUBMITTER: Li G 

PROVIDER: S-EPMC7191696 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature