Analysis of DNA methylation profiles during sheep skeletal muscle development using whole-genome bisulfite sequencing.

ABSTRACT:

Background

DNA methylation is an epigenetic regulatory form that plays an important role in regulating the gene expression and the tissues development.. However, DNA methylation regulators involved in sheep muscle development remain unclear. To explore the functional importance of genome-scale DNA methylation during sheep muscle growth, this study systematically investigated the genome-wide DNA methylation profiles at key stages of Hu sheep developmental (fetus and adult) using deep whole-genome bisulfite sequencing (WGBS).

Results

Our study found that the expression levels of DNA methyltransferase (DNMT)-related genes were lower in fetal muscle than in the muscle of adults. The methylation levels in the CG context were higher than those in the CHG and CHH contexts, and meth

SUBMITTER: Fan Y 

PROVIDER: S-EPMC7191724 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature