Adaptations of Escherichia coli strains to oxidative stress are reflected in properties of their structural proteomes.

ABSTRACT: BACKGROUND:The reconstruction of metabolic networks and the three-dimensional coverage of protein structures have reached the genome-scale in the widely studied Escherichia coli K-12 MG1655 strain. The combination of the two leads to the formation of a structural systems biology framework, which we have used to analyze differences between the reactive oxygen species (ROS) sensitivity of the proteomes of sequenced strains of E. coli. As proteins are one of the main targets of oxidative damage, understanding how the genetic changes of different strains of a species relates to its oxidative environment can reveal hypotheses as to why these variations arise and suggest directions of future experimental work. RESULTS:Creating a reference structural proteome for E. coli allows us to comprehensiv

SUBMITTER: Mih N 

PROVIDER: S-EPMC7191737 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature