Mannose-binding lectin 2 gene polymorphisms and their association with tuberculosis in a Chinese population.

ABSTRACT:

Background

Immune- and inflammation-related genes (IIRGs) play an important role in the pathogenesis of tuberculosis (TB). However, the relationship between IIRG polymorphisms and TB risk remains unknown. In this study, the gene polymorphisms and their association with tuberculosis were determined in a Chinese population.

Methods

We performed a case-control study involving 1016 patients with TB and 507 healthy controls of Han Chinese origin. Sixty-four single-nucleotide polymorphisms (SNPs) belonging to 18 IIRGs were genotyped by the PCR-MassArray assay, and the obtained data was analyzed with χ²-test, Bonferroni correction, and unconditional logistic regression analysis.

Results

We observed significant differences in the allele frequency of LTA rs2229094*C

SUBMITTER: Zhang JX 

PROVIDER: S-EPMC7191747 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature