The Integrated RNA Landscape of Renal Preconditioning against Ischemia-Reperfusion Injury.

ABSTRACT:

Background

Although AKI lacks effective therapeutic approaches, preventive strategies using preconditioning protocols, including caloric restriction and hypoxic preconditioning, have been shown to prevent injury in animal models. A better understanding of the molecular mechanisms that underlie the enhanced resistance to AKI conferred by such approaches is needed to facilitate clinical use. We hypothesized that these preconditioning strategies use similar pathways to augment cellular stress resistance.

Methods

To identify genes and pathways shared by caloric restriction and hypoxic preconditioning, we used RNA-sequencing transcriptome profiling to compare the transcriptional response with both modes of preconditioning in mice before and after renal ischemia-reperfusion injury

SUBMITTER: Johnsen M 

PROVIDER: S-EPMC7191926 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature