Terminally Differentiated Effector Memory CD8⁺ T Cells Identify Kidney Transplant Recipients at High Risk of Graft Failure.

ABSTRACT:

Background

Identifying biomarkers to predict kidney transplant failure and to define new therapeutic targets requires more comprehensive understanding of the immune response to chronic allogeneic stimulation.

Methods

We investigated the frequency and function of CD8⁺ T cell subsets-including effector memory (EM) and terminally differentiated EM (TEMRA) CD8⁺ T cells-in blood samples from 284 kidney transplant recipients recruited 1 year post-transplant and followed for a median of 8.3 years. We also analyzed CD8⁺ T cell reactivity to donor-specific PBMCs in 24 patients who had received living-donor kidney transplants.

Results

Increased frequency of circulating TEMRA CD8⁺ T cells at 1 year post-transplant associated with incre

SUBMITTER: Jacquemont L 

PROVIDER: S-EPMC7191929 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature