Low Serum Insulinlike Growth Factor II Levels Correlate with High BMI in American Indian Adults.

ABSTRACT:

Objective

Insulinlike growth factor II (IGF-II) regulates metabolism and growth. In humans, both positive and negative relationships have been reported between serum IGF-II levels and obesity. This study assessed the relationship between serum IGF-II levels and BMI and determined whether IGF-II levels predict weight gain.

Methods

Serum samples were available from 911 American Indians with a recorded BMI. IGF-II was measured using enzyme-linked immunosorbent assay.

Results

Serum IGF-II levels were negatively correlated with BMI (r = -0.17, P = 4.4 × 10^-7 , adjusted for age, sex, and storage time). The strongest correlation was in participants aged ≥ 30 years (r = -0.28, P = 3.4 × 10^-8 , N = 349), a modest correlation was in participants aged 20 to

SUBMITTER: Muller YL 

PROVIDER: S-EPMC7192225 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature