Purple Potato Extract Promotes Intestinal Epithelial Differentiation and Barrier Function by Activating AMP-Activated Protein Kinase.

ABSTRACT: Perturbation of gut epithelial barrier function induces inflammation and other health problems that originate from the gut. Purple potato contains a high content of beneficial polyphenolic compounds. The objective of this study is to evaluate the effect of purple potato extract (PPE) on intestinal differentiation and barrier function, and explore its underlying mechanism using Caco-2 cells and ex vivo cultured gut tissues. PPE increases transepithelial electrical resistance and decreases FITC-dextran paracellular flux in Caco-2 cells, which are associated with strengthened intestinal epithelial differentiation in both Caco-2 cells and ex vivo guts. Furthermore, PPE treatment enhances AMP-activated protein kinase (AMPK) activity, concomitant with the increased expression of CDX2, a key tran

SUBMITTER: Sun X 

PROVIDER: S-EPMC7192330 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature