Dual transcriptomic and epigenomic study of reaction severity in peanut-allergic children.

ABSTRACT:

Background

Unexpected allergic reactions to peanut are the most common cause of fatal food-related anaphylaxis. Mechanisms underlying the variable severity of peanut-allergic reactions remain unclear.

Objectives

We sought to expand mechanistic understanding of reaction severity in peanut allergy.

Methods

We performed an integrated transcriptomic and epigenomic study of peanut-allergic children as they reacted in vivo during double-blind, placebo-controlled peanut challenges. We integrated whole-blood transcriptome and CD4⁺ T-cell epigenome profiles to identify molecular signatures of reaction severity (ie, how severely a peanut-allergic child reacts when exposed to peanut). A threshold-weighted reaction severity score was calculated for each subject based o

SUBMITTER: Do AN 

PROVIDER: S-EPMC7192362 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature