Clinical Characteristics and Outcome of Children Hospitalized With Scrub Typhus in an Area of Endemicity.

ABSTRACT:

Background

Scrub typhus, caused by Orientia tsutsugamushi, is a major cause of acute febrile illness in children in the rural tropics.

Methods

We recruited 60 febrile pediatric patients with a positive scrub typhus rapid diagnostic test result and 40 healthy controls from Chiang Rai Province in northern Thailand. Diagnosis was confirmed by the detection of (1) O. tsutsugamushi-specific DNA in blood or eschar samples with a polymerase chain reaction assay, (2) a fourfold rise in immunoglobulin M (IgM) titer to ≥1:3200 in paired plasma samples with an indirect immunofluorescence assay (IFA), or (3) a single IgM titer of ≥1:3200 in an acute plasma sample with an IFA. Demographic, clinical, and laboratory data were collected, and patients were followed up for 1 year.

Results<

SUBMITTER: Wangrangsimakul T 

PROVIDER: S-EPMC7192406 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature