Association between statin use, atherosclerosis, and mortality in HIV-infected adults.

ABSTRACT:

Background

While HIV infection is associated with increased cardiovascular risk, benefit from statin is not well established in HIV-infected adults. We assessed whether statins are associated with a decrease in carotid artery intima-media thickness (cIMT) progression and all-cause mortality in HIV-infected adults who are at elevated ASCVD risk and recommended for statins.

Methods

Carotid IMT was measured at baseline and follow-up in 127 HIV-infected adults who meet ACC/AHA criteria to be on statins. Inverse probability of treatment weighting (IPTW) was used to address selection bias. Multivariable models were used to control for baseline characteristics.

Results

28 subjects (22%) were on statins and 99 subjects (78%) were not. Mean cIMT at baseline was 1.2 mm (SD = 0.

SUBMITTER: Phan BAP 

PROVIDER: S-EPMC7192415 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature