Epithelial changes of congenital intestinal obstruction in a rat model.

ABSTRACT:

Introduction

Intestinal atresia is a rare congenital affliction that is often associated with severe bacterial infections despite adequate neonatal surgery. Previous studies have focused on enteric nervous system variations. We hypothesized that epithelial systems (ES) may also be involved in the pathophysiology of postnatal disorders.

Materials and methods

Global gene expression was measured by transcriptomic analysis in a rat model of induced intestinal atresia. The analyses then focused on genes involved in ES (enterocytes and goblet cells). Rat fetus small intestines at various stages of development (ED15, ED17, ED19, and ED21, n = 22), were used as non-operated controls and compared to the upper and lower segments of rat fetus small intestines with an induced atresia (n

SUBMITTER: Ballouhey Q 

PROVIDER: S-EPMC7192479 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature