EnvZ/OmpR Two-Component Signaling: An Archetype System That Can Function Noncanonically.

ABSTRACT: Two-component regulatory systems represent the major paradigm for signal transduction in prokaryotes. The simplest systems are composed of a sensor kinase and a response regulator. The sensor is often a membrane protein that senses a change in environmental conditions and is autophosphorylated by ATP on a histidine residue. The phosphoryl group is transferred onto an aspartate of the response regulator, which activates the regulator and alters its output, usually resulting in a change in gene expression. In this review, we present a historical view of the archetype EnvZ/OmpR two-component signaling system, and then we provide a new view of signaling based on our recent experiments. EnvZ responds to cytoplasmic signals that arise from changes in the extracellular milieu, and OmpR acts canon

SUBMITTER: Kenney LJ 

PROVIDER: S-EPMC7192543 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature