Dynamics of genetic variation in transcription factors and its implications for the evolution of regulatory networks in Bacteria.

ABSTRACT: The evolution of regulatory networks in Bacteria has largely been explained at macroevolutionary scales through lateral gene transfer and gene duplication. Transcription factors (TF) have been found to be less conserved across species than their target genes (TG). This would be expected if TFs accumulate mutations faster than TGs. This hypothesis is supported by several lab evolution studies which found TFs, especially global regulators, to be frequently mutated. Despite these studies, the contribution of point mutations in TFs to the evolution of regulatory network is poorly understood. We tested if TFs show greater genetic variation than their TGs using whole-genome sequencing data from a large collection of Escherichia coli isolates. TFs were less diverse than their TGs across natural i

SUBMITTER: Ali F 

PROVIDER: S-EPMC7192604 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature