Ontology highlight
ABSTRACT:
SUBMITTER: Chow JPH
PROVIDER: S-EPMC7192632 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chow Jeremy P H JPH Cai Yijun Y Chow Daniel T L DTL Chung Steven H K SHK Chau Ka-Chun KC Ng Ka-Ying KY Leung Oscar M OM Wong Raymond M H RMH Law Alan W L AWL Leung Yu-On YO Kwok Sui-Yi SY Leung Yun-Chung YC
PloS one 20200430 4
Arginine deprivation cancer therapy targets certain types of malignancies with positive result in many studies and clinical trials. NEI-01 was designed as a novel arginine-depleting enzyme comprising an albumin binding domain capable of binding to human serum albumin to lengthen its half-life. In the present work, NEI-01 is shown to bind to serum albumin from various species, including mice, rat and human. Single intraperitoneal administration of NEI-01 to mice reduced plasma arginine to undetec ...[more]