Prognostic Role of Androgen Receptor Expression in Surgically Resected Early Breast Cancer Patients.

ABSTRACT:

Purpose

Endocrine therapy is a standard treatment for hormone receptor-positive breast cancer, which accounts for 60%-75% of all breast cancer. Hormone receptor positivity is a prognostic and predictive biomarker in breast cancer. Approximately 50%-80% of breast cancer is also positive for androgen receptor (AR), but the prognostic and predictive value of AR expression in breast cancer is controversial. Here, we investigated AR expression and its prognostic value in patients with surgically resected breast cancer in Korea.

Methods

We retrospectively reviewed the medical records of patients who had surgically resected breast cancer to collect AR expression data and other clinicopathological data. The optimal cut-off for AR positivity was determined using a receiver operating

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7192742 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature