Characterization of hippocampal subfields using ex vivo MRI and histology data: Lessons for in vivo segmentation.

ABSTRACT: Hippocampal subfield segmentation on in vivo MRI is of great interest for cognition, aging, and disease research. Extant subfield segmentation protocols have been based on neuroanatomical references, but these references often give limited information on anatomical variability. Moreover, there is generally a mismatch between the orientation of the histological sections and the often anisotropic coronal sections on in vivo MRI. To address these issues, we provide a detailed description of hippocampal anatomy using a postmortem dataset containing nine specimens of subjects with and without dementia, which underwent a 9.4 T MRI and histological processing. Postmortem MRI matched the typical orientation of in vivo images and segmentations were generated in MRI space, based on the registered an

SUBMITTER: de Flores R 

PROVIDER: S-EPMC7192771 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature