Associations of acetaminophen use during pregnancy and the first year of life with neurodevelopment in early childhood.

ABSTRACT:

Background

Over-the-counter analgesic use during pregnancy, particularly acetaminophen, may be associated with negative developmental outcomes in children.

Objective

Estimate associations of prenatal and early-life exposure to acetaminophen in early childhood with cognitive, motor, and language skills in two birth cohorts.

Methods

The American Project Viva cohort (1217 mother-child pairs enrolled 1999-2002) assessed cognition at approximately 3 years using the Peabody Picture Vocabulary Test and the Wide Range Achievement of Visual Motor Abilities (WRAVMA). The Brazilian 2015 Pelotas Birth Cohort (3818 mother-child pairs) assessed cognition at 2 years using the INTERGROWTH-21st Neurodevelopment Assessment. We used linear regression to estimate associations of acetamin

SUBMITTER: Bertoldi AD 

PROVIDER: S-EPMC7192774 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature