Towards precision medicine for stress disorders: diagnostic biomarkers and targeted drugs.

ABSTRACT: The biological fingerprint of environmental adversity may be key to understanding health and disease, as it encompasses the damage induced as well as the compensatory reactions of the organism. Metabolic and hormonal changes may be an informative but incomplete window into the underlying biology. We endeavored to identify objective blood gene expression biomarkers for psychological stress, a subjective sensation with biological roots. To quantify the stress perception at a particular moment in time, we used a simple visual analog scale for life stress in psychiatric patients, a high-risk group. Then, using a stepwise discovery, prioritization, validation, and testing in independent cohort design, we were successful in identifying gene expression biomarkers that were predictive of high-stre

SUBMITTER: Le-Niculescu H 

PROVIDER: S-EPMC7192849 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature