Hippocampal µ-opioid receptors on GABAergic neurons mediate stress-induced impairment of memory retrieval.

ABSTRACT: Stressful life events induce abnormalities in emotional and cognitive behaviour. The endogenous opioid system plays an essential role in stress adaptation and coping strategies. In particular, the µ-opioid receptor (μR), one of the major opioid receptors, strongly influences memory processing in that alterations in μR signalling are associated with various neuropsychiatric disorders. However, it remains unclear whether μR signalling contributes to memory impairments induced by acute stress. Here, we utilized pharmacological methods and cell-type-selective/non-cell-type-selective μR depletion approaches combined with behavioural tests, biochemical analyses, and in vitro electrophysiological recordings to investigate the role of hippocampal μR signalling in memory-retrieval impairment induce

SUBMITTER: Shi MM 

PROVIDER: S-EPMC7192851 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature