Stress-induced changes in CARF expression determine cell fate to death, survival, or malignant transformation.

ABSTRACT: CARF (Collaborator of ARF) was discovered as an ARF-interacting protein that activated ARF-p53-p21^WAF1 signaling involved in cellular response to a variety of stresses, including oxidative, genotoxic, oncogenic, or telomere deprotection stresses, leading to senescence, growth arrest, or apoptosis. Of note, whereas suppression of CARF was lethal, its enrichment was associated with increased proliferation and malignant transformation of cells. These reports have predicted that CARF could serve as a multi-stress marker with a predictive value for cell fates. Here, we recruited various in vitro stress models and examined their effect on CARF expression using human normal fibroblasts. We demonstrate that CARF levels in stress and post-stress conditions could predict the fate of cells

SUBMITTER: Kalra RS 

PROVIDER: S-EPMC7193007 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature