Identifying <i>Candida albicans</i> Gene Networks Involved in Pathogenicity.

ABSTRACT: Candida albicans is a normal member of the human microbiome. It is also an opportunistic pathogen, which can cause life-threatening systemic infections in severely immunocompromized individuals. Despite the availability of antifungal drugs, mortality rates of systemic infections are high and new drugs are needed to overcome therapeutic challenges including the emergence of drug resistance. Targeting known disease pathways has been suggested as a promising avenue for the development of new antifungals. However, <30% of C. albicans genes are verified with experimental evidence of a gene product, and the full complement of genes involved in important disease processes is currently unknown. Tools to predict the function of partially or uncharacterized genes and generate testable

SUBMITTER: Thomas G 

PROVIDER: S-EPMC7193023 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature