A Literature Review of Gene Function Prediction by Modeling Gene Ontology.

ABSTRACT: Annotating the functional properties of gene products, i.e., RNAs and proteins, is a fundamental task in biology. The Gene Ontology database (GO) was developed to systematically describe the functional properties of gene products across species, and to facilitate the computational prediction of gene function. As GO is routinely updated, it serves as the gold standard and main knowledge source in functional genomics. Many gene function prediction methods making use of GO have been proposed. But no literature review has summarized these methods and the possibilities for future efforts from the perspective of GO. To bridge this gap, we review the existing methods with an emphasis on recent solutions. First, we introduce the conventions of GO and the widely adopted evaluation metrics for gene

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC7193026 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature