Lactobacillus murinus Improved the Bioavailability of Orally Administered Glycyrrhizic Acid in Rats.

ABSTRACT: Intestinal microbiota has been extensively studied in the context of host health benefit, and it has recently become clear that the gut microbiota influences drug pharmacokinetics and correspondingly efficacy. Intestinal microbiota dysbiosis is closely related with liver cirrhosis, especially the depletion of Lactobacillus. Therefore, the bioavailability of orally administered glycyrrhizic acid (GL) was speculated to be influenced under a pathological state. In the present study, L. murinus was isolated and screened for GL bioconversion capacity in vitro. Compared with Lactobacillus rhamnosus and Lactobacillus acidophilus, L. murinus was chosen for further investigation because it has the highest biotransformation rate. Our results showed that L

SUBMITTER: Yuan T 

PROVIDER: S-EPMC7193032 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature