Molecular Mechanism for Protection Against Liver Failure in Human Yellow Fever Infection.

ABSTRACT: Yellow fever (YF) is a viral hemorrhagic fever that typically involves the liver. Brazil recently experienced its largest recorded YF outbreak, and the disease was fatal in more than a third of affected individuals, mostly because of acute liver failure. Affected individuals are generally treated only supportively, but during the recent Brazilian outbreak, selected patients were treated with liver transplant. We took advantage of this clinical experience to better characterize the clinical and pathological features of YF-induced liver failure and to examine the mechanism of hepatocellular injury in YF, to identify targets that would be amenable to therapeutic intervention in preventing progression to liver failure and death. Patients with YF liver failure rapidly developed massive transami

SUBMITTER: Lemos FO 

PROVIDER: S-EPMC7193135 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature