Gut bacterial ClpB-like gene function is associated with decreased body weight and a characteristic microbiota profile.

ABSTRACT:

Background

The chaperone ClpB, a bacterial protein, is a conformational antigen-mimetic of α-melanocyte-stimulating hormone (α-MSH) implicated in body weight regulation in mice. We here investigated the potential associations of gut bacterial ClpB-like gene function with obesity status and gut microbiota in humans.

Results

Gut microbiota ClpB KEGG function was negatively associated with body mass index, waist circumference, and total fat mass (DEXA). The relative abundance (RA) of several phyla and families directly associated with ClpB was decreased in subjects with obesity. Specifically, the RA of Rikenellaceae, Clostridiaceae and not assigned Firmicutes were lower in subjects with obesity and positively associated with gut bacterial ClpB-like gene function (not assigned F

SUBMITTER: Arnoriaga-Rodriguez M 

PROVIDER: S-EPMC7193372 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature