The combined effects of microglia activation and brain glucose hypometabolism in early-onset Alzheimer's disease.

ABSTRACT:

Background

Early-onset Alzheimer's disease (EOAD) is characterized by young age of onset (< 65 years), severe neurodegeneration, and rapid disease progression, thus differing significantly from typical late-onset Alzheimer's disease. Growing evidence suggests a primary role of neuroinflammation in AD pathogenesis. However, the role of microglia activation in EOAD remains a poorly explored field. Investigating microglial activation and its influence on the development of synaptic dysfunction and neuronal loss in EOAD may contribute to the understanding of its pathophysiology and to subject selection in clinical trials. In our study, we aimed to assess the amount of neuroinflammation and neurodegeneration and their relationship in EOAD patients, through positron emission tomography (

SUBMITTER: Tondo G 

PROVIDER: S-EPMC7193377 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature