Glutamine transporters as pharmacological targets: From function to drug design.

ABSTRACT: Among the different targets of administered drugs, there are membrane transporters that play also a role in drug delivery and disposition. Moreover, drug-transporter interactions are responsible for off-target effects of drugs underlying their toxicity. The improvement of the drug design process is subjected to the identification of those membrane transporters mostly relevant for drug absorption, delivery and side effect production. A peculiar group of proteins with great relevance to pharmacology is constituted by the membrane transporters responsible for managing glutamine traffic in different body districts. The interest around glutamine metabolism lies in its physio-pathological role; glutamine is considered a conditionally essential amino acid because highly proliferative cells have a

SUBMITTER: Scalise M 

PROVIDER: S-EPMC7193454 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature