Red blood cell alloimmunization in sickle cell disease: assessment of transfusion protocols during two time periods.

ABSTRACT:

Background

Prevention of red blood cell (RBC) alloimmunization in patients with sickle cell disease (SCD) focuses on phenotypic RBC matching. We assessed alloimmunization among transfused patients with SCD after implementing leukoreduction and prophylactic antigen matching (PAM).

Study design and methods

Retrospective review of transfusion and medical records for SCD patients 18 months to 81 years of age was performed covering two 5-year periods: Period 1, no PAM, occasional leukoreduction, and Period 2, consistent leukoreduction and extended PAM (Rh, Kell, S, Fy, Jk) for patients already alloimmunized. Patients transfused in Period 1 were excluded from Period 2.

Results

A total of 293 patients were transfused in Period 1 and 183 in Period 2. Median time between first

SUBMITTER: Campbell-Lee SA 

PROVIDER: S-EPMC7193458 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature