High Permeation Rates in Liposome Systems Explain Rapid Glyphosate Biodegradation Associated with Strong Isotope Fractionation.

ABSTRACT: Bacterial uptake of charged organic pollutants such as the widely used herbicide glyphosate is typically attributed to active transporters, whereas passive membrane permeation as an uptake pathway is usually neglected. For 1-palmitoyl-2-oleoyl- sn-glycero-3-phosphocholine (POPC) liposomes, the pH-dependent apparent membrane permeation coefficients ( P_app) of glyphosate, determined by nuclear magnetic resonance (NMR) spectroscopy, varied from P_app (pH 7.0) = 3.7 (±0.3) × 10^-7 m·s^-1 to P_app (pH 4.1) = 4.2 (±0.1) × 10^-6 m·s^-1. The magnitude of this surprisingly rapid membrane permeation depended on glyphosate speciation and was, at circumneutral pH, in the range of polar, noncharged molecules. These findings point to

SUBMITTER: Ehrl BN 

PROVIDER: S-EPMC7193547 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature