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Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease.


ABSTRACT:

SUBMITTER: Janjua S 

PROVIDER: S-EPMC7193764 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Phosphodiesterase-4 inhibitors for chronic obstructive pulmonary disease.

Janjua Sadia S   Fortescue Rebecca R   Poole Phillippa P  

The Cochrane database of systematic reviews 20200501


<h4>Background</h4>Chronic obstructive pulmonary disease (COPD) is associated with cough, sputum production or dyspnoea, and a reduction in lung function, quality of life, and life expectancy. Apart from smoking cessation, no other treatments that slow lung function decline are available. Roflumilast and cilomilast are oral phosphodiesterase-4 (PDE₄) inhibitors proposed to reduce the airway inflammation and bronchoconstriction seen in COPD. This Cochrane Review was first published in 2011, and w  ...[more]

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