Mapping Pharmacological Network of Multi-Targeting Litchi Ingredients in Cancer Therapeutics.

ABSTRACT: Considerable pharmacological studies have demonstrated that the extracts and ingredients from different parts (seeds, peels, pulps, and flowers) of Litchi exhibited anticancer effects by affecting the proliferation, apoptosis, autophagy, metastasis, chemotherapy and radiotherapy sensitivity, stemness, metabolism, angiogenesis, and immunity via multiple targeting. However, there is no systematical analysis on the interaction network of "multiple ingredients-multiple targets-multiple pathways" anticancer effects of Litchi. In this study, we summarized the confirmed anticancer ingredients and molecular targets of Litchi based on published articles and applied network pharmacology approach to explore the complex mechanisms underlying these effects from a perspective of system biology. T

SUBMITTER: Cao S 

PROVIDER: S-EPMC7193898 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature