Predictive Nephrotoxicity Profiling of a Novel Antifungal Small Molecule in Comparison to Amphotericin B and Voriconazole.

ABSTRACT:

Background and purpose

Candida albicans is the major fungal species associated with superficial mucosal infections such as oral candidiasis as well as systemic mycoses with high morbidity and mortality. On top of the rising drug resistance, currently available antifungal agents have significant adverse effects. Nephrotoxicity is the major treatment complication associated with antifungal agents.Recently, we discovered a novel antifungal small molecule SM21 with promising antifungal activity. The present study aimed to comparatively evaluate the in vivo and in vitro nephrotoxicity of SM21 comparing with Amphotericin B and voriconazole.

Experimental approach

Nephrotoxicity of SM21 and its analogue were comparatively evaluated with Amphotericin B (AmB) and

SUBMITTER: Udawatte NS 

PROVIDER: S-EPMC7193989 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature