Targeting T cell activation in immuno-oncology.
Ontology highlight
ABSTRACT:
SUBMITTER: Saibil SD
PROVIDER: S-EPMC7193998 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Targeting T cell activation in immuno-oncology.
Current oncology (Toronto, Ont.) 20200401 Suppl 2
The years since 2009 have seen tremendous progress in unlocking the curative potential of the immune system for the treatment of cancer. Much of that revolution in immuno-oncology has been fueled by the clinical success of immune checkpoint inhibitors, particularly those targeting the PD-1 axis. Unfortunately, many patients still fail to benefit from checkpoint blockade or other immunotherapies. An inability to fully activate antitumour T cells contributes in part to the failure of those therapi ...[more]
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