Ontology highlight
ABSTRACT:
SUBMITTER: Furukawa T
PROVIDER: S-EPMC7194077 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Nature communications 20200122 1
The frequency of antifungal resistance, particularly to the azole class of ergosterol biosynthetic inhibitors, is a growing global health problem. Survival rates for those infected with resistant isolates are exceptionally low. Beyond modification of the drug target, our understanding of the molecular basis of azole resistance in the fungal pathogen Aspergillus fumigatus is limited. We reasoned that clinically relevant antifungal resistance could derive from transcriptional rewiring, promoting d ...[more]