Interferon lambda rs368234815 ΔG/ΔG is associated with higher CD4⁺:CD8⁺ T-cell ratio in treated HIV-1 infection.

ABSTRACT:

Background

The objectives of this study were to investigate the relationships between polymorphisms at the interferon lambda (IFNL) locus and CD4⁺:CD8⁺ ratio normalisation in people living with HIV (PLWH) on effective antiretroviral therapy (ART); and to examine whether these polymorphisms influence the composition of T lymphocyte compartments in long-term treated HIV-1 infection.

Methods

A cross-sectional study in PLWH enrolled into the Mater Immunology study. We performed IFNL genotyping on stored samples and evaluated the association of IFNL single-nucleotide polymorphisms (rs368234815 and rs12979860) with CD4⁺:CD8⁺ ratio normalization (> 1) and expanded CD4⁺ and CD8⁺ T-cell subsets; CD45RO⁺CD62L

SUBMITTER: Freitas IT 

PROVIDER: S-EPMC7194102 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature