Visualizing 'omic feature rankings and log-ratios using Qurro.

ABSTRACT: Many tools for dealing with compositional ' 'omics' data produce feature-wise values that can be ranked in order to describe features' associations with some sort of variation. These values include differentials (which describe features' associations with specified covariates) and feature loadings (which describe features' associations with variation along a given axis in a biplot). Although prior work has discussed the use of these 'rankings' as a starting point for exploring the log-ratios of particularly high- or low-ranked features, such exploratory analyses have previously been done using custom code to visualize feature rankings and the log-ratios of interest. This approach is laborious, prone to errors and raises questions about reproducibility. To address these problems we introduc

SUBMITTER: Fedarko MW 

PROVIDER: S-EPMC7194218 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature