Host deficiency in ephrin-A1 inhibits breast cancer metastasis.

ABSTRACT: Background: The conventional dogma of treating cancer by focusing on the elimination of tumor cells has been recently refined to include consideration of the tumor microenvironment, which includes host stromal cells. Ephrin-A1, a cell surface protein involved in adhesion and migration, has been shown to be tumor suppressive in the context of the cancer cell. However, its role in the host has not been fully investigated. Here, we examine how ephrin-A1 host deficiency affects cancer growth and metastasis in a murine model of breast cancer. Methods: 4T1 cells were orthotopically implanted into the mammary fat pads or injected into the tail veins of ephrin-A1 wild-type ( Efna1 ^+/+), heterozygous ( Efna1 ^+/-), or knockout ( Efna1 ^-/-

SUBMITTER: Shiuan E 

PROVIDER: S-EPMC7194498 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature