Ontology highlight
ABSTRACT:
SUBMITTER: Noll KE
PROVIDER: S-EPMC7195006 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Cell reports 20200401 4
Host genetic factors play a fundamental role in regulating humoral immunity to viral infection, including influenza A virus (IAV). Here, we utilize the Collaborative Cross (CC), a mouse genetic reference population, to study genetic regulation of variation in antibody response following IAV infection. CC mice show significant heritable variation in the magnitude, kinetics, and composition of IAV-specific antibody response. We map 23 genetic loci associated with this variation. Analysis of a subs ...[more]