HIF-1α metabolically controls collagen synthesis and modification in chondrocytes.

ABSTRACT: Endochondral ossification, an important process in vertebrate bone formation, is highly dependent on correct functioning of growth plate chondrocytes¹. Proliferation of these cells determines longitudinal bone growth and the matrix deposited provides a scaffold for future bone formation. However, these two energy-dependent anabolic processes occur in an avascular environment^1,2. In addition, the centre of the expanding growth plate becomes hypoxic, and local activation of the hypoxia-inducible transcription factor HIF-1α is necessary for chondrocyte survival by unidentified cell-intrinsic mechanisms^3-6. It is unknown whether there is a requirement for restriction of HIF-1α signalling in the other regions of the growth plate and whether chondrocyte metabolis

SUBMITTER: Stegen S 

PROVIDER: S-EPMC7195049 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature