Grade 1 Acute on Chronic Liver Failure Is a Predictor for Subsequent Grade 3 Failure.

ABSTRACT:

Background and aims

Acute on chronic liver failure (ACLF) results in extremely high short-term mortality in patients with underlying cirrhosis. The European Association for the Study of the Liver criteria grade ACLF severity from 1 (least severe) to 3 (most severe) based on organ failures (OFs) that develop after an acute decompensation (AD). However, the implications of surviving low-grade ACLF in terms of risk of subsequent high-grade ACLF are unclear.

Approach and results

We conducted a retrospective cohort study of patients with compensated cirrhosis in the Veterans Health Administration database from January 2008 to June 2016. Propensity matching for grade 1 (G1) ACLF, followed by Cox regression, was used to model risk of subsequent grade 3 (G3) ACLF. Stratified analyse

SUBMITTER: Mahmud N 

PROVIDER: S-EPMC7195222 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature