The allergenic activity and clinical impact of individual IgE-antibody binding molecules from indoor allergen sources.

ABSTRACT: A large number of allergens have been discovered but we know little about their potential to induce inflammation (allergenic activity) and symptoms. Nowadays, the clinical importance of allergens is determined by the frequency and intensity of their IgE antibody binding (allergenicity). This is a rather limited parameter considering the development of experimental allergology in the last 20 years and the criteria that support personalized medicine. Now it is known that some allergens, in addition to their IgE antibody binding properties, can induce inflammation through non IgE mediated pathways, which can increase their allergenic activity. There are several ways to evaluate the allergenic activity, among them the provocation tests, the demonstration of non-IgE mediated pathways of inflamm

SUBMITTER: Caraballo L 

PROVIDER: S-EPMC7195550 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature