New hydroperoxylated and 20,24-epoxylated dammarane triterpenes from the rot roots of Panax notoginseng.

ABSTRACT:

Background

Root rot is a serious destructive disease of Panax notoginseng, a famous cultivated araliaceous herb called Sanqi or Tianqi in Southwest China.

Methods

The chemical substances of Sanqi rot roots were explored by chromatographic techniques. MS, 1D/2D-NMR, and single crystal X-ray diffraction were applied to determine the structures. Murine macrophage RAW264.7 and five human cancer cell lines were used separately for evaluating the antiinflammatory and cytotoxic activities.

Results and conclusion

Thirty dammarane-type triterpenes and saponins were isolated from the rot roots of P. notoginseng. Among them, seven triterpenes, namely, 20(S)-dammar-25-ene-24(S)-hydroperoxyl-3β,6α,12β,20-tetrol (1), 20(S</

SUBMITTER: Shang JH 

PROVIDER: S-EPMC7195571 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature