Ginsenoside Rk1 is a novel inhibitor of NMDA receptors in cultured rat hippocampal neurons.

ABSTRACT:

Background

Ginsenoside Rk1, a saponin component isolated from heat-processed Panax ginseng Meyer, has been implicated in the regulation of antitumor and anti-inflammatory activities. Although our previous studies have demonstrated that ginsenoside Rg3 significantly attenuated the activation of NMDA receptors (NMDARs) in hippocampal neurons, the effects of ginsenosides Rg5 and Rk1, which are derived from heat-mediated dehydration of ginsenoside Rg3, on neuronal NMDARs have not yet been elucidated.

Methods

We examined the regulation of NMDARs by ginsenosides Rg5 and Rk1 in cultured rat hippocampal neurons using fura-2-based calcium imaging and whole-cell patch-clamp recordings.

Results

The results from our investigation showed that ginsenosides Rg3 and Rg5 inhibi

SUBMITTER: Ryoo N 

PROVIDER: S-EPMC7195591 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature