Systematic review and meta-analysis of case-crossover and time-series studies of short term outdoor nitrogen dioxide exposure and ischemic heart disease morbidity.

ABSTRACT:

Background

Nitrogen dioxide (NO₂) is a pervasive urban pollutant originating primarily from vehicle emissions. Ischemic heart disease (IHD) is associated with a considerable public health burden worldwide, but whether NO₂ exposure is causally related to IHD morbidity remains in question. Our objective was to determine whether short term exposure to outdoor NO₂ is causally associated with IHD-related morbidity based on a synthesis of findings from case-crossover and time-series studies.

Methods

MEDLINE, Embase, CENTRAL, Global Health and Toxline databases were searched using terms developed by a librarian. Screening, data extraction and risk of bias assessment were completed independently by two reviewers. Conflicts between reviewers were reso

SUBMITTER: Stieb DM 

PROVIDER: S-EPMC7195719 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature