Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions.

ABSTRACT:

Background

Hypoxic-ischemic encephalopathy (HIE) has a high morbidity rate and involves severe neurologic deficits, including cerebral palsy. Therapeutic hypothermia (TH) has been shown to decrease the mortality rate and provide neuroprotection in infants with HIE. However, death and disability rates in HIE infants treated with TH remain high. Although the cellular mechanism of the neuroprotective effect of TH remains unclear, astrocytic erythropoietin (EPO) is known to be a key mediator of neuroprotection under hypoxic conditions. In the present study, we investigated the hypothermia effect on EPO expression in astrocytes and determined whether hypothermia attenuates neuronal damage via EPO signaling.

Methods

Astrocytes derived from rat cerebral cortex were cultured under o

SUBMITTER: Toriuchi K 

PROVIDER: S-EPMC7195727 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature