Retinoic acid inducible gene-I mediated detection of bacterial nucleic acids in human microglial cells.

ABSTRACT:

Background

Bacterial meningitis and meningoencephalitis are associated with devastating neuroinflammation. We and others have demonstrated the importance of glial cells in the initiation of immune responses to pathogens invading the central nervous system (CNS). These cells use a variety of pattern recognition receptors (PRRs) to identify common pathogen motifs and the cytosolic sensor retinoic acid inducible gene-1 (RIG-I) is known to serve as a viral PRR and initiator of interferon (IFN) responses. Intriguingly, recent evidence indicates that RIG-I also has an important role in the detection of bacterial nucleic acids, but such a role has not been investigated in glia.

Methods

In this study, we have assessed whether primary or immortalized human and murine glia express RIG

SUBMITTER: Johnson MB 

PROVIDER: S-EPMC7195775 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature