Wg-blimp: an end-to-end analysis pipeline for whole genome bisulfite sequencing data.

ABSTRACT:

Background

Analysing whole genome bisulfite sequencing datasets is a data-intensive task that requires comprehensive and reproducible workflows to generate valid results. While many algorithms have been developed for tasks such as alignment, comprehensive end-to-end pipelines are still sparse. Furthermore, previous pipelines lack features or show technical deficiencies, thus impeding analyses.

Results

We developed wg-blimp (whole genome bisulfite sequencing methylation analysis pipeline) as an end-to-end pipeline to ease whole genome bisulfite sequencing data analysis. It integrates established algorithms for alignment, quality control, methylation calling, detection of differentially methylated regions, and methylome segmentation, requiring only a reference genome and raw s

SUBMITTER: Woste M 

PROVIDER: S-EPMC7195798 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature