Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity.

ABSTRACT:

Background

Impaired endothelium-dependent vasodilation is a hallmark of obesity-induced hypertension. The recognition that Ca²⁺ signaling in endothelial cells promotes vasodilation has led to the hypothesis that endothelial Ca²⁺ signaling is compromised during obesity, but the underlying abnormality is unknown. In this regard, transient receptor potential vanilloid 4 (TRPV4) ion channels are a major Ca²⁺ influx pathway in endothelial cells, and regulatory protein AKAP150 (A-kinase anchoring protein 150) enhances the activity of TRPV4 channels.

Methods

We used endothelium-specific knockout mice and high-fat diet-fed mice to assess the role of endothelial AKAP150-TRPV4 signaling in blood pressure regulation under normal and obese conditions. We

SUBMITTER: Ottolini M 

PROVIDER: S-EPMC7195859 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature